Adult neurogenesis/neurogenesis table

Many factors have been shown to affect the levels of neurogenesis in the adult brain. Most of these affect one of two processes: 1> the proliferation of precursor or stem cells and 2> the survival of immature neurons. It is possible that other processes can be affected as well.

For detailed descriptions and references, see Ming and Song, 2005 and Abrous et al., 2005.

Dentate Gyrus

Regulator	Effect	Target Process
Genetic Background	Increase/Decrease	Proliferation & Survival
Enriched Environment	Increase	Survival
Physical Exercise	Increase	Proliferation
Learning	Increase	Survival
Aging	Decrease	Proliferation
Dietary Restriction	Increase	Survival
Stress	Decrease	Proliferation
Seizure Activity	Increase	Proliferation & Survival
Ischemia	Increase	Proliferation & Survival
Irradiation	Decrease	Proliferation & Survival
Alzheimer’s Disease	Unknown	Proliferation
Huntington’s Disease	Decrease	Proliferation
Parkinson’s Disease	Decrease	Proliferation
Opiates	Decrease	Proliferation
Antidepressants	Increase	Proliferation & Survival
Ethanol	Decrease	Proliferation (?) & Survival

Olfactory Bulb

Regulator	Effect	Target Process
Enriched Odor Environment	Increase	Survival
Physical Exercise	No change
Odor Learning	Increase	Survival
Aging	Decrease	Proliferation
Dietary Restriction	No change
Seizure Activity	Increase	Proliferation & Survival
Ischemia	Increase	Proliferation & Survival
Irradiation	Decrease	Proliferation & Survival
Alzheimer’s Disease	Increase	Proliferation
Huntington’s Disease	Increase	Proliferation
Parkinson’s Disease	Decrease	Proliferation & Survival